P4370 - Outcomes of Needle Knife Stricturotomy (NKSt) and NKSt With Balloon Dilation (NKSt-BD) in Patients With IBD Strictures: A Single Center Experience
Ammad Javaid. Chaudhary, MD1, Muhammad Z. Khan, MD1, Ali Jaan, MD2, Abdullah Sohail, MD3, Diana Jomaa, MD1, Muhammad Shahzil, MD4, Ahila Manivannan, MD1, Hamza Asif, MD5, Abdulmalik Saleem, MD1, Muhammad Saad Faisal, MD1, Taher Jamali, MD6, Muhammad Salman Faisal, MD1, Jason Schairer, MD1 1Henry Ford Health, Detroit, MI; 2Rochester General Hospital, Rochester, NY; 3University of Iowa Hospitals & Clinics, Iowa City, IA; 4Penn State Health Milton S. Hershey Medical Center, Hershey, PA; 5Khyber Teaching Hospital, Peshawar, North-West Frontier, Pakistan; 6Henry Ford Hospital, Detroit, MI
Introduction: In recent years, endoscopic balloon dilatation (BD), and needle knife stricturotomy have emerged as safe and effective options for managing strictures associated with inflammatory bowel disease (IBD). These bowel sparing techniques, individually, have gained popularity and served as an alternative to surgical interventions. In this study, we delve into our tertiary care center’s experience with using these techniques simultaneously, to treat IBD related strictures.
Methods: A retrospective chart review was performed on patients with Crohn’s disease that underwent NKSt alone and NSKt with BD at our tertiary care center between 2018 to 2023. Retrospective demographic, clinical, and procedure-specific information was extracted from the electronic medical record. Patients with strictures related to a disease other than IBD were excluded from the study.All analyses were performed using SAS 9.4 (SAS Institute Inc., Cary, NC).
Results: In this study involving 50 patients with IBD related fibrotic strictures, 39 (78%) patients underwent NKSt intervention, while 11 (22%) underwent simultaneous NKSt with balloon dilation (NKSt-BD). Patients who underwent NKSt-BD were younger (43.0 ± 10.9 vs 51.2 ± 15.8) and predominantly male (72.7%). (Table 1) NKSt alone was the most common intervention in IBD patients with anastomotic strictures (61.5%) while NKSt-BD was used in 6 patients with anastomotic strictures and 5 patients with non-anastomotic strictures. NKSt-BD was used mostly for longer strictures (2.7±1.3 cm) and NKSt without BD was used for relatively shorter strictures (1.2 ± 1 cm). Bleeding was the most common peri-procedural complication (7.7%) followed by abdominal pain (2.5%) in NKSt group. No complications were observed in the NKSt-BD group. Only 4 patients in the NKSt group developed complications within 10 days of procedure.(Table 2) Symptoms recurred in 9 (23%) patients in NKSt group and 2 (18.1%) patients who underwent NKSt-BD. 15 (38.4%) patients in NKSt group and 7 (63.6%) patients in NKSt-BD had to undergo repeat endoscopy; one patient in the NKSt group underwent surgery.
Discussion: Our study demonstrates the clinical and technical success of using NSKt in conjunction with BD compared to NSKt alone. The NSKt-BD group was effective and safer in longer fibrotic strictures, however statistical significance was not achieved likely due to the sample size. More multi-centre studies with larger population size need to be conducted to improve generalizability.
Figure: Table 1. Basic demographic and Clinical Characteristics of IBD Patients who underwent Needle knife stricturotomy vs Needle knife stricturotomy with simultaneous balloon dilation.
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
Disclosures:
Ammad Chaudhary indicated no relevant financial relationships.
Muhammad Khan indicated no relevant financial relationships.
Ali Jaan indicated no relevant financial relationships.
Abdullah Sohail indicated no relevant financial relationships.
Diana Jomaa indicated no relevant financial relationships.
Muhammad Shahzil indicated no relevant financial relationships.
Ahila Manivannan indicated no relevant financial relationships.
Hamza Asif indicated no relevant financial relationships.
Abdulmalik Saleem indicated no relevant financial relationships.
Muhammad Saad Faisal indicated no relevant financial relationships.
Taher Jamali indicated no relevant financial relationships.
Muhammad Salman Faisal indicated no relevant financial relationships.
Jason Schairer indicated no relevant financial relationships.
Ammad Javaid. Chaudhary, MD1, Muhammad Z. Khan, MD1, Ali Jaan, MD2, Abdullah Sohail, MD3, Diana Jomaa, MD1, Muhammad Shahzil, MD4, Ahila Manivannan, MD1, Hamza Asif, MD5, Abdulmalik Saleem, MD1, Muhammad Saad Faisal, MD1, Taher Jamali, MD6, Muhammad Salman Faisal, MD1, Jason Schairer, MD1. P4370 - Outcomes of Needle Knife Stricturotomy (NKSt) and NKSt With Balloon Dilation (NKSt-BD) in Patients With IBD Strictures: A Single Center Experience, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.