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Monday Poster Session

Category: Esophagus

P2236 - Seasons of Eosinophilic Esophagitis: Pinpointing the Summer Summit of Exacerbations

Monday, October 28, 2024
10:30 AM – 4:00 PM ET
Location: Exhibit Hall E
Has Audio

    Presenting Author(s)

  • Chun-Wei Pan, MD

    John H. Stroger, Jr. Hospital of Cook County
    Chicago, IL

Chun-Wei Pan, MD1, Alejandro J. Nieto Dominguez, MD1, Daniel Guifarro, MD1, Maoyin Pang, MD, PhD2
1John H. Stroger, Jr. Hospital of Cook County, Chicago, IL; 2Mayo Clinic, Jacksonville, FL

Introduction: Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition characterized by eosinophilic inflammation of the esophagus. While allergic triggers, including food and aeroallergens, have been implicated, the specific role of aeroallergens in adult EoE exacerbations remains unclear. This study aims to investigate the seasonal patterns of EoE-related emergency department (ED) visits to elucidate the potential role of aeroallergens in triggering acute exacerbations.

Methods: Data from the Healthcare Cost and Utilization Project Nationwide Emergency Department Sample (HCUP NEDS) from 2016-2021 were analyzed. Adult patients diagnosed with EoE were identified using ICD-10 coding (K20.0) in the first three diagnostic positions. Patients from regions experiencing distinct seasons (excluding the South and West) were included. The study analyzed seasonal variations using generalized additive models (GAMs) adjusted for age and sex.

Results: The analysis of 8,467 EoE patients showed significant seasonal variation in ED presentations, with the highest cases in summer (2,320 cases) and the lowest in winter (1,860 cases). Multivariate analysis indicated that the odds of EoE diagnosis were significantly higher in summer (adjusted odds ratio [aOR]: 1.34, 95% CI: 1.02–1.76) compared to winter. GAM analysis demonstrated a peak in EoE cases during July, with the incidence declining through fall and winter (Figure 1).

Discussion: This study demonstrates significant seasonal variation in EoE presentations, with a peak in summer months, suggesting a potential role of aeroallergens in exacerbating EoE. These findings highlight the importance of considering seasonal aeroallergen exposure in managing EoE in adults.

Figure: Figure 1. Seasonal variation in eosinophilic esophagitis presentation in the United States between 2016-2020. Horizontal x-axis is displayed across the month of the presentation. Vertical Axis is showing effect of month on hospitalization


Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.


Disclosures:
Chun-Wei Pan indicated no relevant financial relationships.
Alejandro Nieto Dominguez indicated no relevant financial relationships.
Daniel Guifarro indicated no relevant financial relationships.
Maoyin Pang indicated no relevant financial relationships.


Chun-Wei Pan, MD1, Alejandro J. Nieto Dominguez, MD1, Daniel Guifarro, MD1, Maoyin Pang, MD, PhD2. P2236 - Seasons of Eosinophilic Esophagitis: Pinpointing the Summer Summit of Exacerbations, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.