P1615 - An In-Patient Analysis of Helicobacter pylori Infection in GIST Patients: A Study of Outcomes, Prevalence, and Incidence

Anwar Uddin, MD¹, Prashil Dave, MD², Peter Lymberopoulos, MD¹, Aboud Kaliounji, MD², Narinderjeet Kaur, MD, MS¹, Justin Chung, MD³, Madia Ahad, MD¹, Rafat Uddin, BA¹, Rahat Uddin, MS¹, Afgal Ahad, MD^1
1SUNY Downstate Medical Center, Brooklyn, NY; ²State University of New York Downstate, Brooklyn, NY; ³SUNY Downstate Health Sciences University, Brooklyn, NY

Introduction: Helicobacter pylori, a common bacterial infection, has been associated with various gastrointestinal disorders, and understanding its impact on gastrointestinal stromal tumors (GIST) patients is crucial for optimizing their clinical management. The aim of present study is to examine the prevalence and inpatient outcomes of AGIB in MALToma patients using the nationwide database.

Methods: We used the Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) to identify adult patients admitted with GIST during 2016 – 2020 using ICD-10-CM codes (C49.Ax). We used ICD-10-CM codes to identify patients with H. pylori infection (B96.81). Main outcomes were in-hospital mortality, length of stay (LOS), and hospital costs. We also examined colon cancer, GI bleed, celiac disease, ulcerative colitis (UC), Crohn’s disease (CD) as secondary outcomes. We evaluate the association between H. pylori and outcomes using survey based multivariate logistic regression models for in-hospital mortality and secondary outcomes, Poisson regression for LOS, and generalized linear model with gamma distribution and log link for hospitalization cost. Models were adjusted for age, sex, race and ethnicity, primary payer, Charlson comorbidity index, hospital bed size, hospital region and hospital teaching status.

Results: We identified a total of 47,465 GIST hospitalizations between 2016 and 2020 in the United States and 485 (1.02%) of them were associated with H. pylori infection. In‐patient mortality did not significantly differ in GIST patients with H. pylori vs those without H. pylori (2.1% vs 3.1%, adjusted OR: 0.74, 95%CI: 0.18 - 3.13, P = 0.7, Table 1). GIST patients with H. pylori had an increased length of stay (7.8 ± 0.61 vs 6.1 ± 0.08 days, P = 0.013) and an increased cost of hospitalization ($25,314 ± 2,046 vs $21,236 ± 305, P = 0.039, Table 1). GI bleed was significantly higher in GIST patients with H. pylori (31% vs 13%, adjusted OR: 3.01, 95%CI: 1.95 – 4.65, p < 0.001) while diagnosis of color cancer did not significantly differ between GIST patients with H. pylori infection vs those without H. pylori infection.

Discussion: H. pylori infection in GIST hospitalization is associated with increased risk of GI bleed and higher length of stay and cost of hospitalization.


Disclosures:


Anwar Uddin, MD¹, Prashil Dave, MD², Peter Lymberopoulos, MD¹, Aboud Kaliounji, MD², Narinderjeet Kaur, MD, MS¹, Justin Chung, MD³, Madia Ahad, MD¹, Rafat Uddin, BA¹, Rahat Uddin, MS¹, Afgal Ahad, MD¹. P1615 - An In-Patient Analysis of <i>Helicobacter pylori</i> Infection in GIST Patients: A Study of Outcomes, Prevalence, and Incidence, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.